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Small RNAs

Leaner, meaner siRNAs

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Single-stranded small interfering RNA offers a potent and simple way to silence gene expression in the body.

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References

  1. Lima, W.F. et al. Single-stranded siRNAs activate RNAi in animals. Cell 150, 883–894 (2012).

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  2. Yu, D. et al. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell 150, 895–908 (2012).

    Article  CAS  Google Scholar 

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Nawy, T. Leaner, meaner siRNAs. Nat Methods 9, 1050 (2012). https://doi.org/10.1038/nmeth.2240

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