Single-stranded small interfering RNA offers a potent and simple way to silence gene expression in the body.
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References
Lima, W.F. et al. Single-stranded siRNAs activate RNAi in animals. Cell 150, 883–894 (2012).
Yu, D. et al. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell 150, 895–908 (2012).
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Nawy, T. Leaner, meaner siRNAs. Nat Methods 9, 1050 (2012). https://doi.org/10.1038/nmeth.2240
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DOI: https://doi.org/10.1038/nmeth.2240