By bundling together receptor domains, researchers identify important extracellular protein-protein interactions that are otherwise too weak to detect.
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References
Özkan, E. et al. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell 154, 228–239 (2013).
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Eisenstein, M. Strength in numbers. Nat Methods 10, 823 (2013). https://doi.org/10.1038/nmeth.2627
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DOI: https://doi.org/10.1038/nmeth.2627