Figure 3: NBS of somatic tumor mutations.
(a) Co-clustering matrices for uterine cancer patients, comparing NBS (STRING) (top) to standard consensus clustering (bottom). (b,c) Association of NBS subtypes with histology (b) and composition of NBS subtypes in terms of histological type and tumor grade (c) for uterine cancer. (d,e) Association of NBS subtypes (HumanNet) with patient survival time (d) and Kaplan-Meier survival plots for NBS subtypes (e) for ovarian cancer. (f,g) Association of NBS subtypes (HumanNet) with patient survival time (f) and Kaplan-Meier survival plots for NBS subtypes (g) for lung cancer. (b,d,f) P value of significance of 10−k is indicated by k concentric circles surrounding a data point (for example, three concentric circles indicate P < 0.001); in the case of uterine a significance of 10−5k is indicated by k concentric circles (for example, one circle indicates P < 10−5). Hazard R., hazard ratio, the ratio of fatalities between the two indicated subtypes over the studied time interval.
