Figure 5: Network view of genes with high network-smoothed mutation scores in HumanNet ovarian cancer subtype 1 (relative to scores of other subtypes). | Nature Methods

Figure 5: Network view of genes with high network-smoothed mutation scores in HumanNet ovarian cancer subtype 1 (relative to scores of other subtypes).

From: Network-based stratification of tumor mutations

Figure 5

Subtype 1 had the lowest survival and highest platinum-resistance rates amongst the four recovered subtypes. Node size corresponds to smoothed mutation scores. Node color corresponds to a set of functional classes of interest recovered through manual examination of the resulting network with the aid of the GeneMania Cytoscape plug-in. Thickened node outlines indicate genes that are known cancer genes included in the COSMIC cancer-gene census. An underlined gene symbol in the network indicates that somatic mutations were found for that gene in the examined cohort.

Back to article page