The power of genetics in the worm, and in the bacteria that worms eat, is harnessed for a systems view of the effect of diet on a host organism.
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References
Watson, E. et al. Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits. Cell 156, 759–770 (2014).
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de Souza, N. Interspecies systems biology (a.k.a. interspecies genetics). Nat Methods 11, 372 (2014). https://doi.org/10.1038/nmeth.2917
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DOI: https://doi.org/10.1038/nmeth.2917