Supplementary Figure 6: Combined clustering of cell type– and modification–specific interplay between DNA motifs and the epigenome.

The heat map shows the clustering of 589 motif groups. The dendrogram shows the motif groups clustered by their interplay with epigenomic modification and cell-type. Both motifs that are enriched and depleted from modification peaks are shown. On the side of the heat map furthest from the dendrogram, a histogram shows the number of motifs in each cluster. Furthest from the dendrogram are two plots that show the locations of: (i) motif groups that contain both positive and negative interplay for the same modification (ii) the locations of motif groups that correspond to certain groups proteins that share DNA-binding motifs.