Supplementary Figure 4: Alignment of RRM motifs of human proteins in which cross-linked peptides have been identified. | Nature Methods

Supplementary Figure 4: Alignment of RRM motifs of human proteins in which cross-linked peptides have been identified.

From: Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins

Supplementary Figure 4

Proteins are identified by their gene names. The corresponding recommended protein names can be found in Supplementary Table 1. The number of the respective RRM and the positions of the first and the last residue within the RRM are given next to the sequences. The RNP2 and RNP1 consensus sequences marked with light gray, with conserved aromatic residues in dark gray. Peptides found cross-linked to RNA are underlined, cross-linked regions are highlighted in yellow. If the cross-linked amino acid was identified from the MS/MS fragment spectrum it is shown in red. Overall, eleven cross-linked residues align with the conserved aromatic residues in the RNP2 and RNP1 consensus sequences that are frequently connected to direct protein–RNA contacts.

Back to article page