As the CRISPR-Cas system matures, specificity, efficacy and maybe even a eukaryotic nuclease are being considered.
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Rusk, N. Next-generation CRISPRs. Nat Methods 12, 36 (2015). https://doi.org/10.1038/nmeth.3237
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DOI: https://doi.org/10.1038/nmeth.3237
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