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Chemical biology

A bumpy, holey method to probe proteins

Nature Methods volume 12, page 14 (2015)Cite this article

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A 'bump-and-hole' strategy probes individual BET bromodomains.

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References

  1. Baud, M.G.J. et al. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science 346, 638–641 (2014).

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  1. Allison Doerr
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Doerr, A. A bumpy, holey method to probe proteins. Nat Methods 12, 14 (2015). https://doi.org/10.1038/nmeth.3246

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