Supplementary Figure 2: Effects of mutations on the same protein but on different interaction interfaces and mutations on different proteins but on the two sides of the same interaction interface.

(a) The table shows the number of pairs of mutations, on interaction interfaces of the same protein, that are causing different phenotypes and can be found on interfaces mediated different interactions vs. those that mediated the same interaction. Pairs of mutations on the same proteins but on interfaces mediating different interactions are more likely to cause different phenotypes. (b) The table shows the number of pairs of mutations, on interacting proteins that are causing the same phenotype and can be found on the two sides of the same interfaces vs. those that are on interfaces mediating other interactions. Pairs of mutations on different but interacting proteins that are on opposite sides of the same interface are more likely to cause the same phenotype than pairs of mutations that are on different non interacting interfaces. The different quantities are calculated as detailed in the legend of Supplementary Figure 1.