Supplementary Figure 9: Characteristics of TSE sites compared to non-TSE sites.

(a) Distribution of TSE in different types of intragenic regions. TSE sites that were significantly specific to at least one tissue were included. Similar distribution of Non-TSE sites is shown for comparison purpose. "Noncoding" refers to noncoding genes or noncoding transcripts of coding genes. (b) Empirical cumulative distributions of 3’ UTR length for genes harboring TSE or Non-TSE sites. The longest 3’ UTR span was used if alternative 3’ UTRs exist for a gene overlapping the editing sites. (c) Empirical cumulative distributions of distance between RNA editing sites and the AAUAAA poly A signal. All alternative distances were included in case of alternative 3’ UTRs. (d) Similar as (c), for AUUAAA poly A signal. All p values were calculated using the Kolmogorov–Smirnov test. (e) Percentage of RNA editing sites that overlap existing CLIP-seq binding sites of RNA binding proteins (collected from public CLIP-seq data, see Online Methods). TSEs were more often located in CLIP sites than Non-TSEs (p = 8.1x10-7, Fisher's Exact Test). The error bars show the 95% confidence intervals.