Supplementary Figure 10: Sequence-specific transcription factors distinguish between DNase I–hypersensitive and transcribed regulatory TREs.
From: Identification of active transcriptional regulatory elements from GRO-seq data
(a) TFs are either associated with DNase-I hypersensitive peaks that are actively transcribed (+dREG) or open but non-transcribed (-dREG and DNase-I hypersensitive insulators), as indicated by the presence of Pol II (red rocket). ROC plots depict the accuracy with which these classes of regulatory TRE can be distinguished in three cell types based on the patterns of TF binding. (b) Logistic regression coefficients for each transcription factor correlated with transcription initiation (positive, red) or repression (negative, blue) following a 1,000 sample bootstrap.
