Supplementary Figure 8: Impact of marker genes on deconvolution
From: Robust enumeration of cell subsets from tissue expression profiles
(a) Heat map of signature matrix 1 (SM1), which contains only cell type specific marker genes. (b) Heat map of signature matrix 2 (SM2), which contains only non-cell type specific marker genes. (c) CIBERSORT and DSA deconvolution performance on ten mixtures created using SM1. (d,e) Deconvolution performance on ten mixtures created using SM2: (d) CIBERSORT and RLR, (e) QP, LLSR, and PERT. For details, see Online Methods. Statistical concordance between known and observed cell type proportions was determined by linear regression (dashed lines) and Pearson correlation (R).
