Supplementary Figure 9: Properties of samples containing TP53-R282W.
From: MIMP: predicting the impact of mutations on kinase-substrate phosphorylation
(a) Types of mutations in TP53 across samples with the TP53-R282W mutation. Only four of 23 samples show possibly deleterious mutations, such as frameshift deletions or nonsense mutations. (b) Samples with the rewiring mutation TP53-R282W show mRNA expression levels of TP53 that are similar to other samples. Samples with frameshift deletions (square) or nonsense mutations (triangle) are highlighted as points on the plot. One sample containing a frame shift mutation did not have a measured expression value for TP53. These two observations suggest that our predicted network-rewiring mutations in TP53 are active in corresponding cancer samples.
