Supplementary Figure 5: Effect of number of kinase targets on called pSNVs.
From: MIMP: predicting the impact of mutations on kinase-substrate phosphorylation
Kinases with more experimentally validated targets likely have a larger number of called pSNVs. (a) shows the relationship between the number of experimentally validated kinase targets (after refinement, AUC≥0.6) vs. the number of pSNVs predicted to rewire the kinase. Correlations and their P-values are presented in the top left corner. The line of best fit is shown in red. (b) shows the same data represented in a box plot, showing a significant enrichment of the number of pSNVs for kinases with ≥100 phosphorylation targets. P-value represents enrichment as computed by a one-sided Wilcoxon signed-rank test.
