Supplementary Figure 7: Colocalization and coexpression of rewired kinase-substrate pairs.
From: MIMP: predicting the impact of mutations on kinase-substrate phosphorylation
(a) pSNVs involved in rewiring (dark blue) are more likely to occur in unstructured regions compared to non-rewiring pSNVs (white). P-value above the bar reflects significantly higher number of pSNVs and is computed using one tailed binomial test (b) Expression and localization data were used to show rewired kinase- substrates (blue) are more likely to be co-expressed (left) and co-localized (right) compared to expectation from random kinase-substrate pairs (grey). P-values above bars were computed using the Z-test and represent a significantly higher number of rewiring pSNVs compared to randomly samples kinase-substrate pairs. Error bars represent the 95% confidence intervals.
