Supplementary Figure 7: Comparison of RS-PACT of BphP1-expressing U87 tumor and unlabeled U87 tumor. | Nature Methods

Supplementary Figure 7: Comparison of RS-PACT of BphP1-expressing U87 tumor and unlabeled U87 tumor.

From: Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe

Supplementary Figure 7

In vivo ON state (the first column), OFF state (the second column) differential (the third column), and overlay (the fourth column) PA images of a BphP1-expressing U87 tumor (a) and an unlabeled U87 tumor serving as a control (b). The two types of tumor cells were subcutaneously injected into two different sites on the flank of the same mouse. The differential image of the BphP1-expressing U87 tumor has a substantially superior image contrast to that of the unlabeled tumor. The overlay images show the BphP1 signal in color and the background blood signal in gray. A global threshold was applied to all the differential images with a threshold level at three times the noise level.

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