Supplementary Figure 8: Statistical analysis of lineage segregation.
From: Inverted light-sheet microscope for imaging mouse pre-implantation development
Simplified representation of lineage trees. Color code represents how much a relative contribution of each branch to the ICM or TE lineages deviates from the whole embryo average (white, visible at one cell stage). Branches contributing only to ICM are shown in red and branches contributing only to TE are shown in blue. Probability that observed lineage segregation at 2-, 4-, 8-, 16- or 32-cell stage occurred by chance is shown on the right side of each tree. Probability was estimated using a permutation test where the observed tree was compared to 100,000 trees with randomized fates (Online Methods and Supplementary Note).
