Supplementary Figure 3: Density plots of 100,000 bootstrapping simulations to estimate TP and TN prediction rates with CADD-based MSC, by randomly partitioning 1,283 genes that contain at least 10 mutations in both HGMD and in the 1,000 Genomes Project database.
From: The mutation significance cutoff: gene-level thresholds for variant predictions
(A) TP prediction rate of novel disease-associated deleterious mutations by 90% CI MSC. (B) TN prediction rate of novel disease-associated deleterious mutations by 90% CI MSC. (C) TP prediction rate of novel disease-associated deleterious mutations by 95% CI MSC. (D) TN prediction rate of novel disease-associated deleterious mutations by 95% CI MSC. (E) TP prediction rate of novel disease-associated deleterious mutations by 99% CI MSC. (F) TN prediction rate of novel disease-associated deleterious mutations by 99% CI MSC.
