Supplementary Figure 4: Validation of ATAC-seq library after ATAC-see imaging
From: ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing
a, Schematic workflow of ATAC-seq library preparation after ATAC-see imaging. b, genome-wide comparisons of ATAC-seq reproducibility with Atto-Tn5 on slides from HT1080 cells (HT). c, density plot of differential ATAC-seq peaks fold change (FC)(log2 value) in HT1080(HT) from Atto-Tn5 (on slide) and Nextera Tn5 (in solution) among technical replicates and different enzyme. d, Sensitivity assay (with different input) of global DNA accessibility of ATAC-seq after imaging (on slides) from HT1080 cells.
