A CRISPR–Cas9-based approach identifies synonymous codons that can be reassigned to encode new chemical building blocks.
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References
Wang, K. et al. Defining synonymous codon compression schemes by genome recoding. Nature 539, 59–64 (2016).
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Rusk, N. REXER helps design bacterial genomes. Nat Methods 13, 971 (2016). https://doi.org/10.1038/nmeth.4095
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DOI: https://doi.org/10.1038/nmeth.4095