Supplementary Figure 5: Salmon reduces false isoform switching
From: Salmon provides fast and bias-aware quantification of transcript expression
Transcripts demonstrating dominant isoform switching that results from technical bias. In the quantification estimates computed using kallisto and eXpress, these two-isoform genes show a change in the dominant isoform between conditions (an asterisk denotes a t-test on log2(TPM+1) with p < 1×10−6). However, Salmon directly corrects for technical biases that appear to underlie differences across sequencing center, revealing that the dominant isoform has not, in fact, switched across center.
