Supplementary Figure 3: NMR titration experiments for RRM1 (top) and RRM2 (bottom).

(a) EMCV^E and (b) EMCV^F. The chemical shift perturbations between ¹H¹⁵N-signals of the free and the bound RRMs indicate binding. The signals of the UCUUU-pentaloop of EMCV^F (right) shift upon addition of RRM1 (top) and RRM2 (bottom) due to binding.