Supplementary Figure 10: Effects of mismatches on kmer frequency, accessibility, and variability.
From: chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
(a) Number of peaks containing each kmer 1 mismatch away from ‘AGATAAG’ (b) the average accessibility of peaks containing each kmer 1 mismatch away from ‘AGATAAG’. For (a) and (b) the gray dotted line indicates the value for the ‘AGATAAG’ kmer itself (c) Variability (top) and shared variability of 7mers with 1bp mismatch (bottom) for the top 25 most variable kmers for which no kmer differing by a single base pair had greater variability. For each kmer, the shared variability of each kmer with a single base pair is shown, with the point colored based on the position of the mismatch within the kmer.
