Supplementary Figure 13: chromVAR identifies relevant TFs distinguishing cell types based on scATAC-seq generated via combinatorial indexing protocol.
From: chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
(a) Difference in bias corrected deviations for motifs between GM12878 and HEK293T cells versus the p-value for the difference. Some of the most significant motifs are labelled. Identification of cells as being of one cell type or another was based on the labels previously inferred (Cusanovich et al. 2015). b) Difference in variability of chromatin accessibility associated with motifs between GM12878 and HEK293T cells. c) tSNE visualization of cells using chromVAR as the input. In the top panel, cells are labelled based on the cell type assignments previously inferred (Cusanovich et al. 2015). In the middle and bottom panel, cells are colored based on the deviation z-scores for IRF8 and RELA, respectively, as examples of motifs with greater accessibility (IRF8 and RELA) and greater variability (RELA) in GM1278 cells.
