Supplementary Figure 15: chromVAR identifies TF motifs associated with chromatin accessibility variation across different tissues profiled using DNase-seq by the Roadmap Epigenomics Project.
From: chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
Motifs are based on the collection published by the ENCODE consortium and used for analysis by the Roadmap Epigenomics Project. a) Bias corrected deviations for variable TFs using data down-sampled to approximately 10,000 fragments per sample, b) Bias corrected deviations for variable TFs using full data. c) Enrichment scores computed by the Roadmap Epigenomics Consortium for each cell type based on the enrichment of motifs in various clusters of enhancers and the activity of each cluster in each tissue. For all panels, TFs were chosen based on the variability using the down-sample data, with highly correlated motifs omitted. The row and column ordering were based on clustering of the motifs and samples using the down-sampled data.
