Supplementary Figure 10: Distribution of damaging to benign mutation ratios from patients with no established driver mutation in candidate genes from Supplementary Figure 7 compared to a random expectation

For genes from Supplementary Figure 7 we calculated the ratio of damaging to benign mutations (indicated by a diamond, raw data in Supplementary Table 8 and 9). We compared this ratio to the distribution of ratios from genes matched in size (+-5%) to the gene in question (where the distributions from the random genes can be seen as boxplots). The white line indicates the mean; the box represents 1^st and 3^rd quartile and the white whiskers in the box show the 95% confidence interval. The diamond represents the ratio of the gene indicated under the box. Adj. P values for this analysis for AFF2; E2F4; MY07A; PIK3CB; and RUNX2 are, 1; 1; 0.046, 1; and 1; respectively.