Supplementary Figure 5: Comparison to clustering analysis for the mouse olfactory bulb data. | Nature Methods

Supplementary Figure 5: Comparison to clustering analysis for the mouse olfactory bulb data.

From: SpatialDE: identification of spatially variable genes

Supplementary Figure 5

(A) Principal component analysis using genome-wide expression profiles of individual “spots” for the mouse olfactory bulb data. The spots are color coded by the cluster assignment from conventional Bayesian Gaussian Mixture Modelling (K=4 clusters). (B) Bayesian Gaussian Mixture Model cluster assignment probabilities, discretizing the 260 spatial “spots” into four clusters (analysis ignores spatial structure). (C) Visualization of cluster membership in spatial context of the tissue. (D) Scatter plot of negative log P-values from an ANOVA test between clusters (x-axis) versus negative log P-values from the SpatialDE test. 52 genes were identified by both methods, while 15 genes were unique to SpatialDE. (E) Comparison of clusters of spots versus AEH patterns.

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