Some researchers say an eighty-year-old statistical method can make setting up and analyzing high-throughput screens and large-scale experiments faster and more efficient. So why are more biologists not flocking to use this tool?
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References
Fisher, R.A. The Design of Experiments (Oliver and Boyd, London, 1935).
Carter, C.W. Jr. & Carter, C. W. Protein crystallization using incomplete factorial experiments. J. Biol. Chem. 254, 12219–12223 (1979).
Jancarik, J & Kim, S.H. Sparse matrix sampling: a screening method for crystallization of proteins. J. Appl. Crystallogr. 24, 409–411 (1991).
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Blow, N. High-throughput screening: designer screens. Nat Methods 6, 105–108 (2009). https://doi.org/10.1038/nmeth0109-105
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DOI: https://doi.org/10.1038/nmeth0109-105
