Two approaches using either fosmid clones or a microfluidic device are used to tackle the challenge of a haplotype-resolved human genome.
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References
Fan, H. C. et al. Whole-genome molecular haplotyping of single cells. Nat. Biotechnol. 29, 51–57 (2011).
Kitzman, J.O. et al. Haplotype-resolved genome sequencing of a Gujarati Indian individual. Nat. Biotechnol. 29, 59–63 (2011).
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Rusk, N. One genome, two haplotypes. Nat Methods 8, 107 (2011). https://doi.org/10.1038/nmeth0211-107
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DOI: https://doi.org/10.1038/nmeth0211-107
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