The combination of a DNA probe and mass spectrometric analysis allows the unbiased identification of chromatin-associated proteins.
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References
Déjardin, J. & Kingston, R.E. Purification of proteins associated with specific genomic loci. Cell 136, 175–186 (2009).
Mittler, G. et al. A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements. Genome Res. 19, 284–293 (2009).
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Rusk, N. Reverse ChIP. Nat Methods 6, 187 (2009). https://doi.org/10.1038/nmeth0309-187
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DOI: https://doi.org/10.1038/nmeth0309-187