Abstract
A technique for performing PCR on extremely large DNA molecules offers researchers the ability to generate accurate multi-marker haplotypes for large numbers of patients—even with loci arrayed across entire human chromosomes.
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References
Zhang, K. et al. Long-range polony haplotyping of individual human chromosome molecules. Nat. Genet. 38, 382–387 (2006).
Mitra, R.D. & Church, G.M. In situ localized amplification and contact replication of many individual DNA molecules. Nucleic Acids Res. 27, e34 (1999).
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Eisenstein, M. Putting long-range mapping in reach. Nat Methods 3, 239 (2006). https://doi.org/10.1038/nmeth0406-239
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DOI: https://doi.org/10.1038/nmeth0406-239
