Abstract
Chemists at The Scripps Research Institute demonstrate that it is possible to synthesize complex natural products without the use of protecting groups.
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References
Baran, P.S. et al. Total synthesis of marine natural products without using protecting groups. Nature 446, 404–408 (2007).
O'Malley, D.P. et al. Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide E, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton. J. Am. Chem. Soc.; published online 22 March 2007.
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Doerr, A. Unprotected synthesis. Nat Methods 4, 388 (2007). https://doi.org/10.1038/nmeth0507-388
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DOI: https://doi.org/10.1038/nmeth0507-388
