Abstract
Using customized DNA-cleaving enzymes, researchers can dramatically improve their success rate for homologous recombination in human cells—with potentially powerful implications for gene therapy applications.
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References
Urnov, F.D. et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature; published online 3 April 2005.
Porteus, M.H. & Baltimore, D. Chimeric nucleases stimulate gene targeting in human cells. Science 300, 763 (2003).
Bibikova, M. et al. Enhancing gene targeting with designed zinc-finger nucleases. Science 300, 764 (2003).
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Eisenstein, M. Human genomic repair at your fingertips. Nat Methods 2, 405 (2005). https://doi.org/10.1038/nmeth0605-405
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DOI: https://doi.org/10.1038/nmeth0605-405
