An innovative genetic screen yields new insights into kinase active site structure, expanding the number of enzymes from this family addressable with chemical tools.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Neurotrophin receptor tyrosine kinases regulated with near-infrared light
Nature Communications Open Access 08 March 2019
-
A computational protocol to evaluate the effects of protein mutants in the kinase gatekeeper position on the binding of ATP substrate analogues
BMC Research Notes Open Access 20 February 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout

References
Manning, G., Whyte, D.B., Martinez, R., Hunter, T. & Sudarsanam, S. Science 298, 1912–1934 (2002).
Zhang, C. et al. Nat. Methods 2, 435–441 (2005).
Davies, S.P., Reddy, H., Caivano, M. & Cohen, P. Biochem. J. 351, 95–105 (2000).
Bishop, A. et al. J. Am. Chem. Soc. 121, 627–631 (1999),
Bishop, A.C., et al. Nature 407, 395–401 (2000).
Sekiya-Kawasaki, M. et al. J. Cell Biol. 162, 765–772 (2003).
Weiss, E.L., Bishop, A.C., Shokat, K.M. & Drubin, D.G. Nat. Cell Biol. 2, 677–685 (2000).
Weijland, A. & Parmeggiani, A. Science 259, 1311–1314 (1993).
Powers, T. & Walter, P. Science 269, 1422–1424 (1995).
Hoffman, H.E., Blair, E.R., Johndrow, J.E. & Bishop, A.C. J. Am. Chem. Soc. 127, 2824–2825 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cravatt, B. Kinase chemical genomics—a new rule for the exceptions. Nat Methods 2, 411–412 (2005). https://doi.org/10.1038/nmeth0605-411
Issue date:
DOI: https://doi.org/10.1038/nmeth0605-411
This article is cited by
-
Neurotrophin receptor tyrosine kinases regulated with near-infrared light
Nature Communications (2019)
-
A computational protocol to evaluate the effects of protein mutants in the kinase gatekeeper position on the binding of ATP substrate analogues
BMC Research Notes (2017)
-
Imaging the boundaries—innovative tools for microscopy of living cells and real-time imaging
Journal of Chemical Biology (2008)