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A trinucleotide repeat biosensor

Nature Methods volume 2, page 482 (2005)Cite this article

Abstract

A small-molecule ligand that binds to a (CAG)n hairpin repeat is the basis of a biosensor to detect repeat length, which may help diagnose trinucleotide repeat disease severity.

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Figure 1: Binding of NA to the CAG-CAG triad.

References

  1. Nakatani, K. et al. Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats. Nat. Chem. Biol. 1, 39–43 (2005).

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Authors
  1. Allison Doerr
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Doerr, A. A trinucleotide repeat biosensor. Nat Methods 2, 482 (2005). https://doi.org/10.1038/nmeth0705-482a

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  • DOI: https://doi.org/10.1038/nmeth0705-482a

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