A prototype for a mass spectrometer with single-molecule sensitivity has prospects for single-cell proteomics.
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References
Naik, A.K. et al. Towards single-molecule nanomechanical mass spectrometry. Nat. Nanotechnol. 4, 445–450 (2009).
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Doerr, A. Mass spectrometers on a chip. Nat Methods 6, 555 (2009). https://doi.org/10.1038/nmeth0809-555
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DOI: https://doi.org/10.1038/nmeth0809-555