Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlights
  • Published:

New shapes of prions

Nature Methods volume 6, page 557 (2009)Cite this article

Modification of a system for rapid amplification of misfolded prion proteins allows de novo generation of these infectious molecules and provides a glimpse of the diverse range of possible misfolded prion strains.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Barria, M.A et al. De novo generation of infectious prions in vitro produces a new disease phenotype. PLoS Pathog. 5, e1000421 (2009).

    Article  Google Scholar 

  2. Saborio, G.P et al. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411, 810–813 (2001).

    Article  CAS  Google Scholar 

Download references

Authors
  1. Irene Kaganman
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaganman, I. New shapes of prions. Nat Methods 6, 557 (2009). https://doi.org/10.1038/nmeth0809-556b

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nmeth0809-556b

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing