Cells can be delivered to the rodent brain noninvasively, via the nasal cavity.
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References
Danielyan, L. et al. Intranasal delivery of cells to the brain. Eur. J. Cell Biol. 88, 315–324 (2009).
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de Souza, N. A good nose for stem cells. Nat Methods 6, 562 (2009). https://doi.org/10.1038/nmeth0809-562
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DOI: https://doi.org/10.1038/nmeth0809-562