Abstract
By tinkering with the transposon Sleeping Beauty, researchers have developed new, highly effective strategies for performing mammalian mutagenesis screens.
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References
Collier, L.S. et al. Cancer gene discovery in solid tumors using transposon-based somatic mutagenesis in the mouse. Nature 436, 272–276 (2005).
Dupuy, A.J. et al. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221–226 (2005).
Ivics, Z. et al. Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91, 501–510 (1997).
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Eisenstein, M. Wake-up call for Sleeping Beauty. Nat Methods 2, 637 (2005). https://doi.org/10.1038/nmeth0905-637
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DOI: https://doi.org/10.1038/nmeth0905-637
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