Researchers designed an enzyme to carry out the Diels-Alder reaction, an activity not found in nature.
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References
Siegel, J.B. et al. Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science 329, 309–313 (2010).
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Doerr, A. Unnatural design. Nat Methods 7, 671 (2010). https://doi.org/10.1038/nmeth0910-671
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DOI: https://doi.org/10.1038/nmeth0910-671