Abstract
Using unnatural base pairs, researchers have site-specifically biotinylated RNA, allowing them to immobilize an aptamer on a chip and detect its interaction with a target protein.
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References
Moriyama, K. et al. Site-specific biotinylation of RNA molecules by transcription using unnatural base pairs. Nucleic Acids Res. 33, e129 (2005).
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Kaganman, I. Precisely biotinylated RNA. Nat Methods 2, 730 (2005). https://doi.org/10.1038/nmeth1005-730b
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DOI: https://doi.org/10.1038/nmeth1005-730b
