Channelrhodopsin-2 can be efficiently activated by infrared two-photon excitation light and stimulates action potentials in cultured neurons.
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References
Rickgauer, J.P. & Tank, D.W. Two-photon excitation of channelrhodopsin-2 at saturation. Proc. Natl. Acad. Sci. USA advance online publication (14 August 2009).
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de Souza, N. Two photons as exciting as one. Nat Methods 6, 693 (2009). https://doi.org/10.1038/nmeth1009-693
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DOI: https://doi.org/10.1038/nmeth1009-693