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The Bionas® system bridges the gap between in vivo and in vitro

Nature Methods volume 4, pages iii–iv (2007)Cite this article

Abstract

The Bionas® 2500 system permits for the first time the long-term observation of cell lines, primary cells, tissue slices and biopsies in the presence of drug candidates under close-to-in-vivo conditions. The proprietary perfusion system allows the observation of regeneration effects.

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Figure 1: Oxygen consumption rates of primary human hepatocyte preparations P1 and P2 treated with AAP.
Figure 2: IC50 values of AAP resulting from respiration rates of preparation P2 as measured with the Bionas sensor chip.

References

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Acknowledgements

We thank D. Runge, Primacyt GmbH, for providing the primary hepatocytes and cultivating them on the sensor chips, and S. Duntze, b3c communications, for her support in scientific communications.

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Authors and Affiliations

  1. Bionas GmbH, Friedrich Barnewitz Straße 3, Rostock, 18119, Germany

    Elke Thedinga, Ralf Ehret & Michael Schulze

Authors
  1. Elke Thedinga
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  2. Ralf Ehret
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  3. Michael Schulze
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Corresponding author

Correspondence to Michael Schulze.

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This article was submitted to Nature Methods by a commercial organization and has not been peer reviewed. Nature Methods takes no responsibility for the accuracy or otherwise of the information provided.

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Thedinga, E., Ehret, R. & Schulze, M. The Bionas® system bridges the gap between in vivo and in vitro. Nat Methods 4, iii–iv (2007). https://doi.org/10.1038/nmeth1071

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