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Leave it to cleaver

Abstract

A new strategy for the modulation of ribozyme-mediated RNA cleavage may provide investigators with a powerful system for transgene regulation that bypasses the complications associated with conventional transcriptional control methods.

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Figure 1: An overview of the Mulligan group's strategy for ribozyme-based regulation of gene expression.

RESEARCH PAPERS

  1. Yen, L. et al. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature 431, 471–476 (2004).

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Eisenstein, M. Leave it to cleaver. Nat Methods 1, 95 (2004). https://doi.org/10.1038/nmeth1104-95

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  • DOI: https://doi.org/10.1038/nmeth1104-95

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