Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlights
  • Published:

Tackling biology's big question

Abstract

Working from opposite ends of the protein folding problem, two research teams have developed powerful mathematical strategies that offer the potential to greatly clarify the relationship between primary sequence and native structure.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Mathematical approaches to the protein folding problem.

References

  1. Bradley, P. et al. Toward high-resolution de novo structure prediction for small proteins. Science 309, 1868–1871 (2005).

    Article  CAS  Google Scholar 

  2. Socolich, M. et al. Evolutionary information for specifying a protein fold. Nature 437, 512–518 (2005).

    Article  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Doerr, A. Tackling biology's big question. Nat Methods 2, 803 (2005). https://doi.org/10.1038/nmeth1105-803

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nmeth1105-803

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing