Abstract
A general method of targeting tagged proteins for rapid degradation in the cell promises to provide a powerful alternative to RNA interference (RNAi) for studying the functions of proteins in living cells.
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References
Banaszynski, L.A. et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126, 995–1004 (2006).
Stankunas, K. et al. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol. Cell 12, 1615–1624 (2003).
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Evanko, D. A protein alternative to RNAi. Nat Methods 3, 871 (2006). https://doi.org/10.1038/nmeth1106-871
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DOI: https://doi.org/10.1038/nmeth1106-871
