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Story of C's

Nature Methods volume 3, page 872 (2006)Cite this article

Abstract

Chromosome conformation capture (3C) graduates to a tool for mapping interaction networks, thanks to a clever way of making molecular 'carbon copies'.

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Figure 1: The 3C method captures physical associations between distal genomic regions using cross-linking followed by restriction enzyme (RE) digestion and ligation (1), then cross-link reversal (2).

References

  1. Dostie, J. et al. Chromosome conformation capture carbon copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res. 16, 1299–1309 (2006).

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Authors
  1. Veronique Kiermer
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Kiermer, V. Story of C's. Nat Methods 3, 872 (2006). https://doi.org/10.1038/nmeth1106-872a

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  • DOI: https://doi.org/10.1038/nmeth1106-872a

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