Abstract
An assay integrating chemical screening and suppressor gene determination promises to accelerate the identification of potent antibacterial compounds and their target proteins and to clarify the key features of successful drugs.
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RESEARCH PAPERS
Li, X. et al. Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. Chem. Biol. 11, 1423–1430 (2004).
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Eisenstein, M. Getting past the pump. Nat Methods 1, 186–187 (2004). https://doi.org/10.1038/nmeth1204-186b
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DOI: https://doi.org/10.1038/nmeth1204-186b