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X-ray vision reveals conformational changes

Nature Methods volume 1, pages 188–189 (2004)Cite this article

Abstract

A new study demonstrates that X-ray scattering data can reveal even minor conformational changes induced in a protein after ligand binding, offering a potentially valuable tool to expedite biochemical studies and drug design.

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Figure 1: (a) Conformation of transferrin before and after binding ligand.

RESEARCH PAPERS

  1. Fischetti, R.F. et al. Wide-angle X-ray solution scattering as a probe of ligand-induced conformational changes in proteins. Chem. Biol. 11, 1431–1443 (2004).

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Authors
  1. Michael Eisenstein
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Eisenstein, M. X-ray vision reveals conformational changes. Nat Methods 1, 188–189 (2004). https://doi.org/10.1038/nmeth1204-188

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  • DOI: https://doi.org/10.1038/nmeth1204-188

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